1. How are
the slides processed, and is there a quality control program
for Tissue Array preparation?
Tissues are processed from the point
of fixation in paraformaldehyde until clearing in xylene by
a standardized autoprocessor program. Highly-qualified paraffin-embedded
blocks are sectioned off by a disposable blade in a microtome.
The pathologist differentiates between cancer and pathologic
regions in H&E stained slides. Precise input of the exact
coordinates into a computer program allows
a newly made array block to be constituted by delicately arranging
tissue cores.
The final QC step is completed by the same pathologists
who initially prepared the TMA.
2. Why is the PetaGen tissue array superior?
We have analyzed and addressed nearly
every issue related to current TMA slide needs: large numbers
of tissues of various types; pathologic tissue alongside of
its cancer matching pair from the the same organ; stubborn adherence
of tissues to withstand the strain of the staining procedure;
regular and precise arrangement of section spots; detailed pathological and clinical information attached
not only to the diseased but also the cancer tissues.
And all this at a very reasonable price!
3. What are the limitations of Tissue
Array slides?
A small tissue core may result in an
insufficient number of cells and tissue loss can often occur.
To overcome these limitations, as many tissue cores of appropriate
size are inserted in a duplicate/triplicate
manner as possible under optimal conditions.
4.What kind of information is provided
for each tissue specimen?
The patient's personal information is kept strictly confidential,
but age, sex and diagnosis will be included as a matter of course.
We provide a detailed clinical history of each tissue section
so that each slide can also be used for scientific research
related to the clinical area.